However, I have learned that the more original your manuscript is, the more likely it is to be published. I am not saying that just because your manuscript is bold or pushes the envelope that it is going to be published.
Your writing style is a big determining factor there, along with editing. I have seen publishers send a rejection without bothering with looking at the manuscript because the editing in the query letter was poor.
Be yourself. Write what you like and don’t worry about what is “in” or “popular” at the moment. You never know, what is popular at the time may fade and what you are writing could come in demand.